zinc oxide nanoparticles toxicity

The study used nanoparticulate ZnO (ca. 2014;6(24):15333–15342. Amara S, Slama IB, Mrad I, Rihane N, Khemissi W, El Mir L, Rhouma KB, Abdelmelek H, Sakly M. Hum Exp Toxicol. A comprehensive toxicity study of zinc oxide nanoparticles versus their bulk in Wistar rats: Toxicity study of zinc oxide nanoparticles. 2018 Apr 25;286:60-70. doi: 10.1016/j.cbi.2018.03.008. Microb Pathog. A severe to slight damage was observed in liver tissue in all groups and tissue destruction was seen in kidney only in acute dose treated groups but no specific pathological effect in testis was observed (Fig. HHS After the determined time for every group (21 days for chronic groups and 7 days for acute groups), blood samples were provided from rat hearts and also liver, kidney and testicular tissue were removed for histological studies. 2016 Dec;35(12):1286-1304. doi: 10.1177/0960327116629530. 8, Ref. Antimicrobial activity; Cytotoxicity; Nanoparticles; Nanotechnology; Synthesis; Zinc oxide. 2016 Aug;161:441-9. doi: 10.1016/j.jphotobiol.2016.06.007. Results: Using ICP-MS and fluorescent-labeled ZnO, it is found that ZnO dissolution could happen in culture medium and endosomes. Zinc oxide nanoparticles have also been tested for longer-term toxicity in animals, using both skin tests and experiments in which suspended particles are inhaled. Int J Nanomedicine. In-Vitro cytotoxicity, antibacterial, and UV protection properties of the biosynthesized Zinc oxide nanoparticles for medical textile applications. Zinc oxide nanocomposites show also selective toxicity toward normal and cancerous cells, which is explained by reactive oxygen formation (ROS). J Nanosci Nanotechnol 2010, 10: 8617–8624. They exhibit antibacterial, anti-corrosive, antifungal and UV filtering properties.  |  Wang LJ, Wang L, Ding WJ, Zhang F: Acute toxicity of ferric oxide and zinc oxide nanoparticles in rats. Zinc oxide nanoparticles (ZnO-NPs) are increasingly used in sunscreens, biosensors, food additives, pigments, rubber manufacture, and electronic materials. Effects of zinc oxide nanoparticles and/or zinc chloride on biochemical parameters and mineral levels in rat liver and kidney. They can also be utilized as a self-cleaning coating material on glass and ceramic surfaces. 2012 May 2;12:60. doi: 10.1186/1472-6882-12-60. Corrigendum to "Zinc oxide nanoparticles: synthesis, antiseptic activity and toxicity mechanism" Adv Colloid Interface Sci 249 (2017) 37-52. Zinc oxide nanocomposites show also selective toxicity toward normal and cancerous cells, which is explained by reactive oxygen formation (ROS). Introduction: Epub 2015 Nov 6. In this study, we investigated the effect of various concentrations of zinc oxide (ZnO) NPs (0, 1, 5, 20, 100, and 1000 mg kg −1 of soil) on lettuce (Lactuca sativa L.) and carrot (Daucus carota subsp. Toxicity of zinc oxide nanoparticles on adult male Wistar rats. With the wide application of ZnO-NPs, concern has been raised about its unintentional health and environmental impacts. 2014 Nov;33(11):1150-7. doi: 10.1177/0960327113510327. After standard phases of preparation, injections were done intraperitoneally in chronic groups with zinc oxide nanoparticles (20 and 40 mg/kg) every other day and for acute groups with 200 and 400 mg/kg in a single dose. However, their potential toxicological impact on environmental microorganisms is largely unexplored. 2020 Sep 30;8:778. doi: 10.3389/fchem.2020.00778. Mechanistic study on antibacterial action of zinc oxide nanoparticles synthesized using green route. It indicates an important role of Zn 2 + ions in the cytotoxicity of zinc oxide nanoparticles. Bobrowska-Korczak B, Gątarek P, Skrajnowska D, Bielecki W, Wyrebiak R, Kovalczuk T, Wrzesień R, Kałużna-Czaplińska J. Nutrients. A severe to slight damage was observed in liver tissue … Many microorganisms exist in the range from hundreds of nanometers to tens of micrometers. The nanoparticles (NPs) have been increasingly manufactured in industry because of the well-known characteristics such as high reactivity, electromagnetic properties and high antibacterial property [].Zinc oxide nanoparticle (nZnO), one of the most popular manufactured metal oxide nanomaterials, has unique properties (i.e., surface area and reactive sites) due to the extremely small … ZnO NPs exhibit attractive antimicrobial properties against bacteria (Gram-positive and Gram-negative) and fungi. Azizi S, Mohamad R, Bahadoran A, Bayat S, Rahim RA, Ariff A, Saad WZ. Zinc oxide (ZnO) has been characterized as a “Generally Recognized as Safe” (GRAS) compound by the US FDA and exhibits minimal toxicity to humans. Epub 2018 Mar 15. ZnO nanopowders are available as powders and dispersions. Mohd Yusof H, Abdul Rahman N, Mohamad R, Zaidan UH, Samsudin AA. 30 nm) showed that small particles in aquatic systems and their bioavailability does not have to be significantly greater than that of larger particles. It is now widely recognized that dissolution plays an important role in metallic nanoparticle toxicity, but to what extent remains unclear. Khan MF, Husain FM, Zia Q, Ahmad E, Jamal A, Alaidarous M, Banawas S, Alam MM, Alshehri BA, Jameel M, Alam P, Ahamed MI, Ansari AH, Ahmad I. ACS Omega. sativus) plants. 2015;25(4):334-9. doi: 10.3109/15376516.2015.1045654. This article provides further detail on the properties and applications of zinc oxide nanoparticles (ZnO). 2015 Oct;84:154-60. doi: 10.1016/j.fct.2015.08.019. 2020 Dec 10;5(50):32203-32215. doi: 10.1021/acsomega.0c03634. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Would you like email updates of new search results? Anti-quorum Sensing and Anti-biofilm Activity of Zinc Oxide Nanospikes. Zinc oxide nanoparticles (ZnO NPs) are being utilized in an increasing number of fields and commercial applications. 2018 Dec;125:252-261. doi: 10.1016/j.micpath.2018.09.030. HHS Yet despite the potentially interesting antitumor activity of ZnO nanoparticles, it has been proven that they can be also cytotoxic and genotoxic for multiple types of human cells (i.e. Biosynthesis of zinc oxide nanoparticles using. ISRN Toxicol 2013; 2013: 316075. Several studies of ZnO NPs cytotoxicity have been conducted and they have shown that zinc oxide nanoparticles can affect many different animal cells , , , , , , , , , . Epub 2015 May 18. ZnO nanomaterials can be used in industry as nano-optical and nano-electrical devices, in food packaging and in medicine as antimicrobial and antitumor agents. A combined toxicity study of zinc oxide nanoparticles and vitamin C in food additives. Furthermore, zinc oxide nanoparticles induced cytotoxicity in human lung epithelial cells via inducing oxidative stress in a concentration-dependent manner, resulting in DNA damage and apoptosis [36 Sahu D, Kannan GM, Vijayaraghavan R, Anand T, Khanum F. Nanosized zinc oxide induces toxicity in human lung cells. ZnO induced toxicity in both cells, leading to the generation of reactive oxygen species (ROS), oxidant injury, excitation of inflammation, and cell death. Please enable it to take advantage of the complete set of features!  |  Epub 2014 Feb 5. In the present study, it was found that ZnO‐engineered nanoparticle (ZnO‐EN) toxicity to the marine diatom Thalassiosira pseudonana could be solely explained by … The current hazard assessment of the emerging chemical contaminant, zinc oxide nanoparticles (ZnO-NPs), seldom considers the influence of environmental factors. Franklinet al. Clipboard, Search History, and several other advanced features are temporarily unavailable. Keywords: neuronal or epithelial cells). Antibacterial activity of zinc oxide nanoparticles (ZnO-NPs) has received significant interest worldwide particularly by the implementation of nanotechnology to synthesize particles in the nanometer region. Yet despite the potentially interesting antitumor activity of ZnO nanoparticles, it has been proven that they can be also cytotoxic and genotoxic for multiple types of human cells (i.e. Would you like email updates of new search results? J Photochem Photobiol B. ; nano-zinc oxide; oxidative stress. Epub 2018 Sep 18. While their general toxicity and associated oxidative stress have been extensively studied, the toxicological pathways that they induce in developmental stages are still largely unknown. The ZnO nanomaterials release into the aquatic ecosystems through domestic and industrial wastewaters has the potential to induce pernicious effects on fish and other organisms. In the present study 36 male Wistar rats with approximate age of two months and weighing 300±30 g were selected. Animals Recent Advances in Nanotechnology-Aided Materials in Combating Microbial Resistance and Functioning as Antibiotics Substitutes. Keywords: The increasing focus on nano zinc oxide resulted in the invention and development of methods of nanoparticles synthesis. Abbasalipourkabir R, Moradi H, Zarei S, Asadi S, Salehzadeh A, Ghafourikhosroshahi A, Mortazavi M, Ziamajidi N. Food Chem Toxicol. NLM Role of quercetin and arginine in ameliorating nano zinc oxide-induced nephrotoxicity in rats. Copyright © 2017 Elsevier B.V. All rights reserved. Król A, Pomastowski P, Rafińska K, Railean-Plugaru V, Buszewski B. Adv Colloid Interface Sci. 2020 Oct 2;15:7329-7358. doi: 10.2147/IJN.S265934. USA.gov.  |  It has been shown that maximum exposure concentration of zinc oxide (125 mg/l) suspension released 6.8 mg/l of Zn 2+ ions. Zinc is a Block D, Period 4 element, while Oxygen is a Block P, Period 2 element. USA.gov.  |  2018 Apr;254:100. doi: 10.1016/j.cis.2018.04.006. Sci Rep. 2020 Nov 17;10(1):19996. doi: 10.1038/s41598-020-76402-w. Jain D, Shivani, Bhojiya AA, Singh H, Daima HK, Singh M, Mohanty SR, Stephen BJ, Singh A. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. ZnO-NPs exhibit attractive antibacterial properties due to increased specific surface area … CAS Article PubMed Google Scholar Please enable it to take advantage of the complete set of features! High luminescent efficiency, a wide band gap (3.36eV), and a large exciton binding energy (60meV) has triggered intense research on the production of nanoparticles using different synthesis methods and on their future applications. Zinc oxide nanoparticles are nanoparticles of zinc oxide (ZnO) that have diameters less than 100 nanometers. The aim of this work was to investigate the sensitivity and adaptability of five bacterial species isolated from sewage towards Ag and ZnO NPs. Appl Microbiol Biotechnol. Hidden toxicity of zinc oxide nanoparticles. NIH eCollection 2020. Zinc oxide nanoparticles (ZnO NPs) are being utilized in an increasing number of fields and commercial applications. This study investigates the toxic effects of ZnO-NPs in human lung cells. 45. Zitao Zhou, Jino Son, Bryan Harper, Zheng Zhou, Stacey Harper, Influence of surface chemical properties on the toxicity of engineered zinc oxide nanoparticles to embryonic zebrafish, Beilstein Journal of Nanotechnology, 10.3762/bjnano.6.160, 6, (1568-1579), (2015). DOI: 10.1007/s40820-015-0040-x Corpus ID: 3669662. Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism @article{Sirelkhatim2015ReviewOZ, title={Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism}, author={Amna Sirelkhatim and S. Mahmud and A. Seeni and Noor Haida Mohamad Kaus and Ling Chuo Ann and S. K. M. Bakhori and … Toxic effect of nano-zinc oxide There were significant decreases in lymphocytes and platelet counts and significant increases in white blood cells count, hemoglobin and hematocrit in acute dose compared to control group and no difference in red blood cells count in all groups. Int J Nanomedicine. Zinc oxide nanoparticles (ZnO-NPs) are among nanoscale materials displaying exponentially growing production due to their applications in the field of cosmetology, medicine, as antibacterial agent and catalyst. This site needs JavaScript to work properly. Zinc oxide nanoparticles induced cyto- and genotoxicity in kidney epithelial cells. Toxicity is a combined effect of zinc oxide nanoparticles and Zn 2+ ions released in the aqueous medium. Epub 2016 Feb 9. Toxicity of zinc oxide nanoparticles is concentration and solubility dependent. The obtained nanoparticles can be characterized with a broad range of analytical methods including dynamic light scattering (DLS), electron microscopy (TEM, SEM), UV-VIS spectroscopy, X-ray diffraction (XRD) or inductively coupled plasma with mass spectrometry (ICP-MS). Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties. 2018 Dec 20;14:87-100. doi: 10.2147/IJN.S186888. We evaluate the potential of zinc oxide nanoparticles as innovative anti-tumor agents by summarizing important results of current studies in this field and discuss the proposed mechanisms that give zinc oxide nanoparticles a selective toxicity for tumor cells. Xia T, Kovochich M, Liong M, et al. Faddah LM, Abdel Baky NA, Al-Rasheed NM, Al-Rasheed NM, Fatani AJ, Atteya M. BMC Complement Altern Med. 10.1166/jnn.2010.2483. However, under seasonal variation and global climate change, marine organisms are exposed to a changing environment with different regimes of temper Environmental Science: Nano Recent HOT Articles Accute Toxicity Satureja ZnO Nanoparticles Bioassay Test LC 50 96h Abstract Nanoparticles are commonly synthesized chemically and because of their risk for living was carried out to evaluate the acute toxicity of zinc oxide nanoparticles synthesized from Satureja hortensis on rainbow trout (Oncorhynchus mykiss) by static bioassay test. Environmental Science and Pollution Research 2019 , 26 (3) , … eCollection 2019. Nowadays, a lot of studies were carried out about side effects of nanoparticles especially nano-zinc oxide, but unfortunately, most of these studies have been conducted with high doses. Effect of Zinc Supplementation on the Serum Metabolites Profile at the Early Stage of Breast Cancer in Rats. Clipboard, Search History, and several other advanced features are temporarily unavailable. Silver and zinc oxide nanoparticles (Ag and ZnO NPs) are widely used as antimicrobial agents.  |  Epub 2016 Jun 7. Zinc oxide nanoparticles (ZnO NPs) are used in an increasing number of industrial products such as rubber, paint, coating, and cosmetics. Toxicity of zinc oxide nanoparticles through oral route Surekha Pasupuleti, Srinivas Alapati, Selvam Ganapathy, Goparaju Anumolu, Neelakanta Reddy Pully, and Balakrishna Murthy Prakhya Toxicology and Industrial Health 2011 28 : 8 , 675-686 There were significant decreases in lymphocytes and platelet counts and significant increases in white blood cells count, hemoglobin and hematocrit in acute dose compared to control group and no difference in red blood cells count in all groups. In the past two decades, ZnO NPs have become one of the most popular metal oxide nanoparticles in biological applications due to their excellent biocompatibility, economic, and low toxicity. Biotechnological aspects of ZnO nanoparticles: overview on synthesis and its applications. 43). NIH Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism View 0 peer reviews of Review on Zinc Oxide Nanoparticles: Antibacterial Activity and Toxicity Mechanism on Publons COVID-19 : add an open review or score for a COVID-19 paper now to ensure the latest research gets the extra scrutiny it needs. 12 ):1286-1304. doi: 10.1177/0960327113510327 Advances in Nanotechnology-Aided Materials in Combating Resistance! 6.8 mg/l of Zn 2+ ions bacterial species isolated from sewage towards and... Rajeshkumar S. Chem Biol Interact NM, Fatani AJ, Atteya M. Complement... 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